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金沢大学附属病院 精神科 医局の紹介

橋本 隆紀



略 歴
1989(H01)年3月  新潟大学医学部医学科卒業 医師国家試験合格
1992(H04)年3月  総合研究大学院大学生命科学研究科生理科学専攻卒業 
1992(H04)年3月  博士(学術)取得
1992(H04)年4月  岡崎国立研究機構生理学研究所神経化学部門
1993(H05)年4月  東京都職員共済組合清瀬病院 神経科
1995(H07)年4月  国立精神神経センター
1997(H09)年4月  科学技術振興事業団 心表象プロジェクト 研究員
2000(H12)年9月  ピッツバーグ大学 精神医学部門 研究員
2003(H15)年7月  ピッツバーグ大学 精神医学部門 助教授
2007(H19)年5月  金沢大学大学院 脳情報病態学(精神医学)准教授
2008(H20)年4月  ピッツバーグ大学 精神医学部門 客員助教授
2014(H26)年3月  ピッツバーグ大学 精神医学部門 客員准教授


資 格
精神保健指定医 精神科専門医

専 門
統合失調症の病態メカニズム


最近の原著論文
Georgiev D, Yoshihara T, Kawabata R, Matsubara T, Tsubomoto M, Minabe Y, Lewis DA, Hashimoto T. Cortical gene expression after a conditional knockout of 67 kDa glutamic acid decarboxylase in parvalbumin neurons. Schizophrenia Bulletin, in press

Ono Y, Kikuchi M, Hirosawa T, Hino S, Nagasawa T, Hashimoto T, Munesue T, Minabe Y. Reduced prefrontal activation during performance of the Iowa Gambling Task in patients with bipolar disorder. Psychiatry Research 233:1-8, (2015)

Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Hashimoto T, Tsubokawa T, Takahashi T, Suzuki M, Higashida H, Minabe Y. Reduced long-range functional connectivity in young children with autism spectrum disorder. Social Cognitive & Affective Neuroscience 10 (2): 248-254 (2015)

Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, Lewis DA, Hashimoto T. Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex of subjects with schizophrenia American J Psychiatry 171:62-71 (2014)

Volk DW*, Matsubara T*, Li S, Sengupta EJ, Georgiev D, Minabe Y, Sampson A, Hashimoto T, Lewis DA. Deficit in transcriptional regulators in cortical parvalbumin neurons in schizophrenia. American Journal of Psychiatry 169:1082-1091 (2012) (*co-first author)

Selective Expression of KCNS3 Potassium Channel α-Subunit in Parvalbumin-Containing GABA Neurons in the Human Prefrontal Cortex, Georgiev D, González-Burgos G, Kikuchi M, Minabe Y, Lewis DA and Hashimoto T, PLoS ONE 7:e43904 (2012)

Hirosawa T, Kikuchi M, Higashida H, Okumura E, Ueno S, Shitamichi K, Yoshimura Y, Munesue T, Tsubokawa T, Haruta Y, Nakatani H, Hashimoto T, Minabe Y. Oxytocin attenuates feelings of hostility depending on emotional context and individuals’ characteristics, Scientific Reports 2:384 (2012)

Kikuchi M, Hashimoto T, Nagasawa T, Hirosawa T, Minabe Y, Yoshimura M, Strik W, Dierks T, Koenig T. Frontal areas contribute to reduced global coordination of resting-state gamma activities in drug-naive patients with schizophrenia. Schizophrenia Res 130(1-3):187-94 (2011).

Beneyto M, Abbott A, Hashimoto T, Lewis DA, Lamina-specific Alterations in Cortical GABAA Receptor Subunit Expression in Schizophrenia Cerebral Cortex 21:999-1101 (2011)

Kikuchi M, Shitamichi K, Ueno S, Yoshimura, Remijn GB, Nagao K, Munesue T, Iiyama K, Tsubokawa T, Haruta Y, Inoue Y, Watanabe K, Hashimoto T, Higashida H, Minabe Y. Neurovascular coupling in the human somatosensory cortex: a single trial study. Neuroreport 21:1106-1110 (2010)

Hashimoto T, Nugyen QL, Rotaru D, Keenan T, Arion D, Beneyto M, Gonzalez-Burgos G, Lewis DA, Protracted Postnatal Developmental Trajectories of GABAA Receptor α1 andα2 subunit Expression in Primate Prefrontal Cortex Biol Psychiatry 65:1015-23 (2009)

Maldonado-Avilés JG, Curley AA, Hashimoto T, Lewis DA, Altered Markers of Tonic Inhibition in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia. Am J Psychiatry Am J Psychiatry 166:450-459 (2009)

Tseng K, Lewis B, Hashimoto T, Sesack S, Kloc M, Lewis DA, and
O'Donnell P, A neonatal ventral hippocampal lesion causes functional deficits in adult prefrontal cortical neurons, J Neurosci 28:12691-12699 (2008)

Eggan SM, Hashimoto T, Lewis DA, Reduced Cortical Cannabinoid 1 Receptor mRNA and Protein Expression in Schizophrenia, Arch Gen Psychiatry 65:772-784 (2008)

Hashimoto T, Bazmi HH, Mirnics K, Wu Q, Sampson AR, and Lewis DA. Conserved Regional Patterns of GABA-Related Transcript Expression in the Neocortex of Subjects with Schizophrenia, Am J Psychiatry 165: 479-489 (2008)

Morris HM, Hashimoto T, Lewis DA. Alterations in somatostatin mRNA expression in the dorsolateral prefrontal cortex of subjects with schizophrenia, Cerebral Cortex 18: 1575-1587 (2008)

Hashimoto T, Arion D, Unger T, Maldonado-Avilés JG, Morris HM, Volk DW, Mirnics K, and Lewis DA. Alterations in GABA-Related Transcriptome in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia, Molecular Psychiatry 13:147-161 (2008)

Gonzalez-Burgos, G, Hashimoto T, Lewis DA. Inhibition and Timing in Cortical Neural Circuits. Am J Psychiatry 164:1:12 (2007)

Glorioso C, Sabatini M, Unger T, Hashimoto T, Monteggia LM, Lewis DA and Mirnics K, Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood, Molecular Psychiatry 11:633-648 (2006)

Hill JJ, Hashimoto T and David A. Lewis, Molecular Mechanisms Contributing to Dendritic Spine Alterations in the Prefrontal Cortex of Subjects with Schizophrenia, Molecular Psychiatry 11: 557-566 (2006)

Hashimoto T and David A. Lewis, BDNF Val66Met polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophrenia, Am J Psychiatry 163:534-537 (2006)

Lewis DA, Hashimoto T, Volk DW. Cortical Inhibitory Neurons and Schizophrenia Nature Review Neuroscience 6: 312-324 (2005)

Hill J, Kolluri N, Hashimoto T, Wu Q, Sampson AR, Monteggia LM, and Lewis DA, Analysis of Pyramidal Neuron Morphology in an Inducible Knockout of Brain Derived Neurotrophic Factor. Biol Psychiatry 57: 932-934 (2005)

Hashimoto T, Bergen SE, Nguyen QL, Xu B, Monteggia LM, Pierri JN, Sun Z, Sampson AR, and Lewis DA, Relation of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 25 (2):372-383 (2005)

Hashimoto T, Volk DW, Lewis DA. GABA neurons in the human prefrontal cortex. Am J Psychiatry 161:10 1764 (2004)

Lewis DA, Volk DW, Hashimoto T. Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction. Psychopharmacology (Berl). 174:143-50 (2004)

Hashimoto T, Volk DW, Eggan, SM, Mirnics K, Pierri, JN, Sun Z, Sampson AR, and Lewis DA. Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci 23 (15): 6315-6326, (2003)

受賞歴
日本統合失調症研究会 第3回研究助成 最優秀賞 (2009)

Young Investigator Awards from the National Alliance for Research on Schizophrenia and Depression, NYC, USA (2006)

Sidney R. Baer, Jr. Prize from the National Alliance for Research on Schizophrenia and Depression, NYC, USA (2005)

Travel Award for Excellent Presentation at the 28th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan (2005)

Young Investigator Awards from the National Alliance for Research on Schizophrenia and Depression, NYC, USA (2004)

Best Poster Award in Workshop on Synaptic Dysfunction and Schizophrenia at Instito Juan March de Estudios e Investigaciones, Madrid, Spain (2003)

Best Presentation Award in the third annual research day (Oral presentation part), University of Pittsburgh, Pittsburgh, USA (2003)


学会シンポジウム等
「統合失調症と大脳皮質パルブアルブミンニューロ ン」第37回生物学 的精神医学会ランチョンセミナー 2015.9.24 (東京・タワーホール船堀)

「統合失調症における大脳皮質パルブアルブミンニューロン選択的遺伝子発現」国際シンポジウム「皮質GABA細胞の異 常と精神神経疾患」(座長)第38回日本神 経科学大会 2015.7.30 (神戸国際会議場)

「統合失調症の認知機能障害の分子メカニズム:大脳皮質パルブアルブミン陽性ニューロンにおけるKCNS3遺伝子の発現変化」第9回日本統合失調症学会 シンポジウム 「次世代のトランスレーショナルリサーチ」2014.3.15(京都)

「大脳皮質GABAニューロンサブタイプ選択的に発現する遺伝子の同定と統合失調症における変化」第34回日本生物学的精神医学会 シンポジウム「統合失調症におけるGABA機能障害」2012.9.29(神戸)

“New molecular markers of GABA neurons subsets in the human cerebral cortex” 第37回日本脳科学会 Keynote Presentation 2010 10.17(天津, 中華人民共和国)

「死後脳からみた統合失調症の病態」第106回日本精神神経学会学術総会 教育講演 2010.5.24 (広島)

「統合失調症と大脳皮質GABA 伝達障害」 第31回日本生物学的精神医学会 シンポジウム「死後脳研究:その成果と課題」2009.4.24(京都)

“Protracted development of prefrontal inhibitory circuitry and schizophrenia” 第4回日本統合失調症学会 シンポジウム「統合失調症の未病と予防」 2009. 1.31(大阪)

“Cortical GABA Neurotransmission in Schizophrenia: Molecular and Regional Phenotypes” 第54回日本神経化学会大会 アニュアルシンポジウム“Translational Research in Neurochemistry” 2008.9.12 (富山)

“Molecular Markers of Cortical GABA Neurotransmission in Schizophrenia: Regional and Cellular Phenotypes” The 63rd Society for Biological Psychiatry Annual Meeting, Symposium: “The Epigenetic Promoter Hypermethylation in GABAergic Neurons as Treatment Target of Psychosis” 2008.5.1 (Washington DC, USA)

“Cell Type-Specific Alterations in Prefrontal GABA Circuits in Schizophrenia: Implications for Pathophysiology-based Treatment Interventions” The 29th CINP Meeting Symposium: “Prospective Treatment of GABAergic Downregulation in Schizophrenia” 2006.7.13 (Chicago, USA)




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